I have vanilla mIRC but am looking for something different. I know there are certain scripts that completely overhaul the entire client (such as NoName Script). Besides NNS, what other scripts are you guys using and what do you think of them? Advantages, disadvantages, features, etc?

When you get tired of mIRC, you may want to try kvirc. It's much more cfgable and quite decent, also multiplatform and FREE.

I used eXtreme script for a while, got tired
nbs-irc is also a nice script for those interested in fancy shit
now I just use vanilla + media displayer(that's the name of it on mircscripts.org)